Characterization Of CTL Clones Isolated From Bone Marrow Transplant Recipient With HLA-Cw-Mismatched Donor

Graft-Versus-Host Disease Transplant Recipient with Acute HLA-Cw-Mismatched Bone Marrow CTL Clones Isolated from an

Bone marrow and peripheral blood stem cell transplant: a bioinformatics approach for mismatched donor recipient pairs.

Bone marrow and peripheral blood stem cell transplants when performed outside the family require high resolution matching of donor and recipient for human leukocyte antigen loci. Marrow registries like National Marrow Development Program in developed countries maintain record of donors and provide most suitable donor when a recipient needs a transplant. Being outside families and due to lack of...

Bone marrow donor registries: discordance in HLA frequencies between donor and recipient populations.

We read with interest the article by Sonnenberg et a1 describing the relationship between registry size and the probability of finding completely and partially HLA-matched unrelated marrow donors.’ The effect of a significant difference in HLA profiles between donor and potential recipient populations was simulated by using two groups of different ethnic origin and was shown to drastically alte...

Molecular characterization of HLA-C incompatibilities in HLA-ABDR-matched unrelated bone marrow donor-recipient pairs. Sequence of two new Cw alleles (Cw*02023 and Cw*0707) and recognition by cytotoxic T lymphocytes.

While the influence of HLA-AB and -DRB1 matching on the outcome of bone marrow transplantation (BMT) with unrelated donors is clear, the evaluation of HLA-C has been hampered by its poor serological definition. Because the low resolution of standard HLA-C typing could explain the significant number of positive cytotoxic T lymphocyte precursor frequency (CTLpf) tests found among HLA-AB-subtype, ...

Anti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion

Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...